Issue 18, 2015

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Abstract

DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.

Graphical abstract: Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Supplementary files

Article information

Article type
Communication
Submitted
11 Dec 2014
Accepted
28 Jan 2015
First published
28 Jan 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 3816-3819

Author version available

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

S. Ordanini, N. Varga, V. Porkolab, M. Thépaut, L. Belvisi, A. Bertaglia, A. Palmioli, A. Berzi, D. Trabattoni, M. Clerici, F. Fieschi and A. Bernardi, Chem. Commun., 2015, 51, 3816 DOI: 10.1039/C4CC09709B

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