Biologically relevant DNA sequences were assembled onto addressable cyclopeptide scaffolds through sequential oxime and CuAAc reactions. The resulting conjugates are able to fold into well-defined anti-parallel DNA G-quadruplex structures, which exhibit high stability and reduced polymorphism.
R. Bonnet, T. Lavergne, B. Gennaro, N. Spinelli and E. Defrancq, Chem. Commun., 2015, 51, 4850 DOI: 10.1039/C4CC09744K
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