Issue 13, 2015

Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform

Abstract

A multifunctional nitric oxide (NO) delivery nanoplatform that combines functionalities of target directing, fluorescence tracking, and photo-controlled target attacking was developed. The {Ru-NO@TiO2 NPs} nanoplatform selectively targeted folate-receptor over-expressed cancer cells while being simultaneously traced based on its inherent fluorescence. Intracellular localized NO and singlet oxygen were produced on demand by controlled visible light illumination, producing a synergistic cytotoxic effect to cancer cells.

Graphical abstract: Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform

Supplementary files

Article information

Article type
Communication
Submitted
10 Dec 2014
Accepted
23 Dec 2014
First published
23 Dec 2014

Chem. Commun., 2015,51, 2555-2558

Author version available

Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform

H. Xiang, L. An, W. Tang, S. Yang and J. Liu, Chem. Commun., 2015, 51, 2555 DOI: 10.1039/C4CC09869B

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