Issue 13, 2015

Direct cross-coupling of benzyl alcohols to construct diarylmethanes via palladium catalysis

Abstract

A direct arylation to furnish diarylmethanes from benzyl alcohols was realized through Pd(PPh3)4-catalyzed Suzuki–Miyaura coupling via benzylic C–O activation in the absence of any additives. The arylation is compatible with various functional groups. This development provides an atom- and step-economic way to approach a diarylmethane scaffold under mild and environmentally benign conditions.

Graphical abstract: Direct cross-coupling of benzyl alcohols to construct diarylmethanes via palladium catalysis

Supplementary files

Article information

Article type
Communication
Submitted
17 Dec 2014
Accepted
21 Dec 2014
First published
22 Dec 2014

Chem. Commun., 2015,51, 2683-2686

Author version available

Direct cross-coupling of benzyl alcohols to construct diarylmethanes via palladium catalysis

Z. Cao, D. Yu, R. Zhu, J. Wei and Z. Shi, Chem. Commun., 2015, 51, 2683 DOI: 10.1039/C4CC10084K

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