Issue 27, 2015

Combining a sensor and a pH-gated nanopore based on an avidin–biotin system

Abstract

Here we propose a new approach to tailor nanopores, which combines both pH gating and sensing properties. This strategy is based on PEG like-avidin grafting in nanopores designed by atomic layer deposition (ALD). Below pH 5 the nanopore is blocked. We show that the PEG chains are at the origin of these properties.

Graphical abstract: Combining a sensor and a pH-gated nanopore based on an avidin–biotin system

Supplementary files

Article information

Article type
Communication
Submitted
17 Dec 2014
Accepted
27 Feb 2015
First published
27 Feb 2015

Chem. Commun., 2015,51, 5994-5997

Author version available

Combining a sensor and a pH-gated nanopore based on an avidin–biotin system

M. Lepoitevin, G. Nguyen, M. Bechelany, E. Balanzat, J. Janot and S. Balme, Chem. Commun., 2015, 51, 5994 DOI: 10.1039/C4CC10087E

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