Issue 28, 2015
From the journal:

Chemical Communications

A ratiometric fluorescent molecular probe for visualization of mitochondrial temperature in living cells†

Mitsumasa Homma,a   Yoshiaki Takei,a   Atsushi Murata,a   Takafumi Inouea  and  Shinji Takeoka*a  

* Corresponding authors

a Department of Life Science & Medical Bioscience, Graduate School of Advanced Science & Engineering, Waseda University, TWins 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan
E-mail: takeoka@waseda.jp

Abstract

Mitochondrial thermodynamics is the key to understand cellular activities related to homeostasis and energy balance. Here, we report the first ratiometric fluorescent molecular probe (Mito-RTP) that is selectively localized in the mitochondria and visualize the temperature. We confirmed that Mito-RTP could work as a ratiometric thermometer in a cuvette and living cells.

Graphical abstract: A ratiometric fluorescent molecular probe for visualization of mitochondrial temperature in living cells

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Article information

DOI
https://doi.org/10.1039/C4CC10349A
Article type
Communication
Submitted
27 Dec 2014
Accepted
26 Feb 2015
First published
26 Feb 2015

Chem. Commun., 2015,51, 6194-6197

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A ratiometric fluorescent molecular probe for visualization of mitochondrial temperature in living cells

M. Homma, Y. Takei, A. Murata, T. Inoue and S. Takeoka, Chem. Commun., 2015, 51, 6194 DOI: 10.1039/C4CC10349A

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