Issue 23, 2014
From the journal:

CrystEngComm

Non-contact-mode AFM induced versus spontaneous formed phenytoin crystals: the effect of layer thickness

Heike M. A. Ehmann,a   Thomas Kellnera  and  Oliver Werzer*a  

* Corresponding authors

a Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, University of Graz, 8010 Graz, Austria
E-mail: oliver.werzer@uni-graz.at

Abstract

In this work the model substance phenytoin is vacuum deposited onto a silica substrate resulting in amorphous films. Crystallization is obtained via the AFM tip as it moves in close vicinity of the surface in non-contact mode. The formed crystals show strong differences depending on the initial layer thickness and in comparison with spontaneously formed crystals.

Graphical abstract: Non-contact-mode AFM induced versus spontaneous formed phenytoin crystals: the effect of layer thickness

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Article information

DOI
https://doi.org/10.1039/C4CE00424H
Article type
Communication
Submitted
28 Feb 2014
Accepted
23 Apr 2014
First published
23 Apr 2014

CrystEngComm, 2014,16, 4950-4954

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Non-contact-mode AFM induced versus spontaneous formed phenytoin crystals: the effect of layer thickness

H. M. A. Ehmann, T. Kellner and O. Werzer, CrystEngComm, 2014, 16, 4950 DOI: 10.1039/C4CE00424H

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