Issue 13, 2014

The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

Abstract

The OPEP coarse-grained protein model has been applied to a wide range of applications since its first release 15 years ago. The model, which combines energetic and structural accuracy and chemical specificity, allows the study of single protein properties, DNA–RNA complexes, amyloid fibril formation and protein suspensions in a crowded environment. Here we first review the current state of the model and the most exciting applications using advanced conformational sampling methods. We then present the current limitations and a perspective on the ongoing developments.

Graphical abstract: The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

Supplementary files

Article information

Article type
Review Article
Submitted
28 Jan 2014
First published
23 Apr 2014

Chem. Soc. Rev., 2014,43, 4871-4893

Author version available

The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

F. Sterpone, S. Melchionna, P. Tuffery, S. Pasquali, N. Mousseau, T. Cragnolini, Y. Chebaro, J. St-Pierre, M. Kalimeri, A. Barducci, Y. Laurin, A. Tek, M. Baaden, P. H. Nguyen and P. Derreumaux, Chem. Soc. Rev., 2014, 43, 4871 DOI: 10.1039/C4CS00048J

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