Issue 3, 2015

Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

Abstract

A mild one-pot methodology has been developed to deracemise rac-2-phenyl-1-propanol by combining the use of non-selective laccase/TEMPO-mediated oxidation with enantioselective bioreduction of the racemic aldehyde intermediate under dynamic conditions. The process was easily scalable and stereocontrollable by selecting the suitable biocatalyst.

Graphical abstract: Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

Supplementary files

Article information

Article type
Communication
Submitted
15 Oct 2014
Accepted
21 Jan 2015
First published
22 Jan 2015
This article is Open Access
Creative Commons BY license

Catal. Sci. Technol., 2015,5, 1443-1446

Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

A. Díaz-Rodríguez, N. Ríos-Lombardía, J. H. Sattler, I. Lavandera, V. Gotor-Fernández, W. Kroutil and V. Gotor, Catal. Sci. Technol., 2015, 5, 1443 DOI: 10.1039/C4CY01351D

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