Issue 5, 2015

Nickel(ii) complexes with a flexible piperazinyl moiety: studies on DNA and protein binding and catecholase like properties

Abstract

Four new mononuclear Ni(II) complexes [Ni(L1)]ClO4 (1a), [Ni(L2)]ClO4(1b), [Ni(SCN)3(CH3OH)(aminoethylpiperazineH)] (2a), and [Ni(DMSO)4(aminoethylpiperazineH)](ClO4)3(2b)have been synthesized from two Schiff base ligands [L1 = 1-phenyl-3-((2-(piperidin-4-yl)ethyl)imino)but-1-en-1-ol and L2 = 4-((2-(piperazin-1-yl)ethyl)imino)pent-2-en-2-ol] by exploiting the flexibility of the piperazinyl moiety. Structural analysis reveals that 1a and 1b are square planar complexes with piperazine rings in boat conformations whereas hydrolysis of Schiff bases (L1 and L2) occurs during formation of octahedral complexes (2a and 2b) with piperazine rings in chair conformations. Screening tests were conducted to quantify the binding ability of complexes (1a, 1b and 2a) towards DNA, BSA and HSA and it was found that square planar complexes (1a and 1b) showed more effective binding properties over octahedral complex (2a). Furthermore, enzyme kinetic studies reflect that square planar complexes (1a and 1b) are also effective in mimicking catecholase like activities over octahedral complex (2a). Among all the complexes, 1a was found to be the most promising molecule among the series due to its large binding affinity towards different bio-macromolecules and higher T.O.N in the catechol oxidation reaction.

Graphical abstract: Nickel(ii) complexes with a flexible piperazinyl moiety: studies on DNA and protein binding and catecholase like properties

Supplementary files

Article information

Article type
Paper
Submitted
02 Sep 2014
Accepted
02 Dec 2014
First published
02 Dec 2014

Dalton Trans., 2015,44, 2299-2310

Author version available

Nickel(II) complexes with a flexible piperazinyl moiety: studies on DNA and protein binding and catecholase like properties

M. Das, R. Nasani, M. Saha, S. M. Mobin and S. Mukhopadhyay, Dalton Trans., 2015, 44, 2299 DOI: 10.1039/C4DT02675F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements