Issue 9, 2015

New insights into the mechanism of iron-catalyzed cross-coupling reactions

Abstract

The mechanism of the iron-catalyzed cross-coupling of alkyl halides with aryl Grignard reagents is studied by a combination of GC monitoring and DFT calculation. Herein, we investigate two possible reaction pathways, the regular oxidative addition (OA) pathway and the atom transfer (AT) pathway that might occur in the rate-limiting step. The computational studies revealed that the AT pathway requires less energy than the regular OA pathway.

Graphical abstract: New insights into the mechanism of iron-catalyzed cross-coupling reactions

Supplementary files

Article information

Article type
Communication
Submitted
14 Nov 2014
Accepted
26 Jan 2015
First published
26 Jan 2015

Dalton Trans., 2015,44, 3959-3962

Author version available

New insights into the mechanism of iron-catalyzed cross-coupling reactions

A. Bekhradnia and P. Norrby, Dalton Trans., 2015, 44, 3959 DOI: 10.1039/C4DT03491K

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