Issue 34, 2015

Ruthenium(ii) polypyridyl complexes as dual inhibitors of telomerase and topoisomerase

Abstract

One novel ruthenium polypyridyl complex, [Ru(bpy)2(icip)]2+ (1), and two previously reported ruthenium polypyridyl complexes, [Ru(bpy)2(pdppz)]2+ (2) and [Ru(bpy)2(tactp)]2+ (3) (bpy = 2,2′-bipyridine, icip = 2-(indeno[2,1-b]chromen-6-yl)-1H-imidazo[4,5-f][1,10]phenanthroline, pdppz = phenanthro[4,5-abc]dipyrido[3,2-h:2′,3′-j]phenazine, tactp = 4,5,9,18-tetraazachryseno[9,10-b]-triphenylene), have been synthesised. As expected, these complexes show inhibition towards telomerase by inducing and stabilising the G-quadruplex structure, and behave as topoisomerase I/II poisons at the same time. Additionally, the acute and chronic cytotoxicities of the complexes are considered. Furthermore, cell apoptosis experiments are used to briefly study the mechanism. Because studies involving multi-target inhibition towards topoisomerase and telomerase of Ru(II) complexes have not been reported previously, the present research may help to develop innovative chemical strategies and therapies.

Graphical abstract: Ruthenium(ii) polypyridyl complexes as dual inhibitors of telomerase and topoisomerase

Supplementary files

Article information

Article type
Paper
Submitted
22 Nov 2014
Accepted
07 Jan 2015
First published
07 Jan 2015

Dalton Trans., 2015,44, 15145-15156

Ruthenium(II) polypyridyl complexes as dual inhibitors of telomerase and topoisomerase

G. Liao, X. Chen, J. Wu, C. Qian, Y. Wang, L. Ji and H. Chao, Dalton Trans., 2015, 44, 15145 DOI: 10.1039/C4DT03585B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements