Issue 2, 2015

Curcumin improves high glucose-induced INS-1 cell insulin resistance via activation of insulin signaling

Abstract

Curcumin is a yellow pigment isolated from Corcuma longan. This research investigates the improvement of curcumin on INS-1 cells with insulin resistance induced by high glucose. INS-1 cells were treated with high glucose (30 mmol L−1) for 48 h. Subsequently, the medium was replaced with curcumin for 24 h. Curcumin effectively increased insulin gene expression and glucose stimulated insulin secretion (GSIS) in a dose-dependent manner. Furthermore, the molecular mechanism of curcumin-induced insulin expression and secretion in high glucose-induced INS-1 cells was investigated in this study. Curcumin increased the expression of glucose transporter 2 (GLUT2) and phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS1), phosphatidylinositol-3-kinase (PI3K) and AKT in the INS-1 cells. Moreover, curcumin stimulation increased the expression of PDX-1 and GCK. This investigation suggests that curcumin prevented high glucose-reduced insulin expression and secretion through activation of the PI3K/Akt/GLUT2 pathway in INS-1 cells.

Graphical abstract: Curcumin improves high glucose-induced INS-1 cell insulin resistance via activation of insulin signaling

Article information

Article type
Paper
Submitted
11 Jul 2014
Accepted
01 Oct 2014
First published
01 Oct 2014

Food Funct., 2015,6, 461-469

Curcumin improves high glucose-induced INS-1 cell insulin resistance via activation of insulin signaling

Z. Song, H. Wang, L. Zhu, M. Han, Y. Gao, Y. Du and Y. Wen, Food Funct., 2015, 6, 461 DOI: 10.1039/C4FO00608A

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