Issue 5, 2014

C(sp3)–C(sp3) bond formation via copper/Brønsted acid co-catalyzed C(sp3)–H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes

Abstract

A copper/Brønsted acid dual-catalyst promoted oxidative cross-dehydrogenative-coupling of alkylazaarenes and tertiary amines for C(sp3)–C(sp3) bond formation was developed. This method uses dioxygen as the terminal oxidant under mild reaction conditions and would provide a convenient benzylic C–H transformation of alkylazaarenes to biologically active pharmaceutics.

Graphical abstract: C(sp3)–C(sp3) bond formation via copper/Brønsted acid co-catalyzed C(sp3)–H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes

Supplementary files

Article information

Article type
Communication
Submitted
09 Jan 2014
Accepted
29 Jan 2014
First published
31 Jan 2014

Green Chem., 2014,16, 2428-2431

C(sp3)–C(sp3) bond formation via copper/Brønsted acid co-catalyzed C(sp3)–H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes

F. Wang, C. Luo, G. Deng and L. Yang, Green Chem., 2014, 16, 2428 DOI: 10.1039/C4GC00038B

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