Issue 6, 2014

Catalyst-free direct arylsulfonylation of N-arylacrylamides with sulfinic acids: a convenient and efficient route to sulfonated oxindoles

Abstract

A simple, efficient and catalyst-free procedure has been developed for the construction of sulfonated oxindoles via the direct arylsulfonylation of N-arylacrylamides with sulfinic acids. The present protocol, which simply utilizes cheap oxidants, readily-available starting materials, and catalyst-free conditions, provides an alternative and highly attractive approach to a series of sulfonated oxindoles with high atom efficiency and excellent functional group tolerance.

Graphical abstract: Catalyst-free direct arylsulfonylation of N-arylacrylamides with sulfinic acids: a convenient and efficient route to sulfonated oxindoles

Supplementary files

Article information

Article type
Communication
Submitted
12 Feb 2014
Accepted
15 Mar 2014
First published
18 Mar 2014

Green Chem., 2014,16, 2988-2991

Author version available

Catalyst-free direct arylsulfonylation of N-arylacrylamides with sulfinic acids: a convenient and efficient route to sulfonated oxindoles

W. Wei, J. Wen, D. Yang, J. Du, J. You and H. Wang, Green Chem., 2014, 16, 2988 DOI: 10.1039/C4GC00231H

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