Issue 4, 2015

Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction

Abstract

This work reports a copper-catalyzed novel protocol for the tandem synthesis of 2-benzimidazolone derivatives from dimethyl carbonate (DMC) and various 2-nitroanilines by using polymethylhydrosiloxane (PMHS) as an inexpensive, stable and environmentally benign reducing agent. This methodology is applicable for the preparation of a broad range of biologically active 2-benzimidazolone derivatives with a good scope in good to excellent yields.

Graphical abstract: Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction

Supplementary files

Article information

Article type
Paper
Submitted
07 Dec 2014
Accepted
02 Feb 2015
First published
02 Feb 2015

Green Chem., 2015,17, 2480-2486

Author version available

Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction

D. B. Nale and B. M. Bhanage, Green Chem., 2015, 17, 2480 DOI: 10.1039/C4GC02408G

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