Issue 8, 2015

A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

Abstract

Magnetite decorated with gold nanoparticles (Fe3O4–AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4–AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (ϕ = 10 nm) decorated with AuNPs (ϕ = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications.

Graphical abstract: A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
18 Dec 2014
Accepted
17 Feb 2015
First published
17 Feb 2015

Lab Chip, 2015,15, 1835-1841

A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

F. C. Cabrera, A. F. A. A. Melo, J. C. P. de Souza, A. E. Job and F. N. Crespilho, Lab Chip, 2015, 15, 1835 DOI: 10.1039/C4LC01483A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements