Issue 2, 2015
From the journal:

MedChemComm

Polymeric micelles for hydrogen sulfide delivery†

Urara Hasegawa*ab  and  André J. van der Vliesbc  

* Corresponding authors

a Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan
E-mail: urara.hasegawa@chem.eng.osaka-u.ac.jp
Fax: +81-6-6879-7367
Tel: +81-6-6879-7365

b Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan

c Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan

Abstract

Polymeric micelles for therapeutic delivery of hydrogen sulfide (H2S) were developed. The micelles released H2S in murine macrophages and enhanced proinflammatory responses induced by a toll-like receptor 7 ligand, gardiquimod. This micellar H2S delivery system may have potential in immunotherapy and vaccine development.

Graphical abstract: Polymeric micelles for hydrogen sulfide delivery

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Article information

DOI
https://doi.org/10.1039/C4MD00373J
Article type
Concise Article
Submitted
29 Aug 2014
Accepted
20 Oct 2014
First published
21 Oct 2014

Med. Chem. Commun., 2015,6, 273-276

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Polymeric micelles for hydrogen sulfide delivery

U. Hasegawa and A. J. van der Vlies, Med. Chem. Commun., 2015, 6, 273 DOI: 10.1039/C4MD00373J

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