Chitosan nanoparticles as a green and renewable catalyst in the synthesis of 1,4-dihydropyridine under solvent-free conditions

Abstract

In the present study, chitosan nanoparticles were obtained by the gelation of chitosan by heptamolybdate anions and dried with dry CO₂ for 30 minutes. Chitosan nanoparticles efficiently proceeded the Hantzsch reaction at 80 °C under metal and solvent free conditions. The present method offers several advantages such as a simple procedure, green conditions, excellent yields and short reaction time.