Targeted delivery of photoactive diazido PtIV complexes conjugated with fluorescent carbon dots

Xiao-Dong Yang; Hui-Jing Xiang; Lu An; Shi-Ping Yang; Jin-Gang Liu

doi:10.1039/C4NJ01758G

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Targeted delivery of photoactive diazido Pt^IV complexes conjugated with fluorescent carbon dots†

Xiao-Dong Yang,‡^a Hui-Jing Xiang,‡^a Lu An,^b Shi-Ping Yang^b and Jin-Gang Liu*^a

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* Corresponding authors

^a Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, P. R. China
E-mail: liujingang@ecust.edu.cn

^b Key Laboratory of Resource Chemistry of MOE & Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, P. R. China

Abstract

A novel Pt^IV–azide@carbon dots (CDs) nanoplatform for photo-controlled targeted platinum drug delivery was developed. The Pt^IV–N₃–FA@CDs nanoplatform selectively targeted folate-receptor overexpressed cancer cells while being simultaneously traced based on its inherent fluorescence; and it showed no dark cytotoxicity even in the presence of reducing glutathione, whereas it was readily photo-activated by either UV or visible light, producing cytotoxicity at a level comparable with that of cisplatin.

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Article information

DOI: https://doi.org/10.1039/C4NJ01758G
Article type: Letter
Submitted: 09 Oct 2014
Accepted: 04 Nov 2014
First published: 06 Nov 2014

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New J. Chem., 2015,39, 800-804

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Targeted delivery of photoactive diazido Pt^IV complexes conjugated with fluorescent carbon dots

X. Yang, H. Xiang, L. An, S. Yang and J. Liu, New J. Chem., 2015, 39, 800 DOI: 10.1039/C4NJ01758G

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