Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines

Abstract

An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium. The remarkable features of this method are mild reaction conditions, short reaction times, easy workup procedure, recyclability of the catalyst and excellent yields of the products. The reaction involves a [3+3] annulation–oxidation sequence and the protocol is useful for synthesizing a broad range of biologically significant pyrimidine derivatives.