Issue 9, 2014

Polyketide biosynthesis in dinoflagellates: what makes it different?

Abstract

Covering: up to 2013

Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the successful biosynthetic experiments that have been reported, many surprising and unique processes have been discovered. This knowledge has been accessed through a series of biochemical labeling studies, and while limited molecular genetic data has been amassed, it is still in the early stages of development. In an attempt to meet this challenge, this review has compared some of the biosynthetic processes with similar ones identified in other microbes such as bacteria and myxobacteria, with the idea that similar genes and enzymes are employed by dinoflagellates.

Graphical abstract: Polyketide biosynthesis in dinoflagellates: what makes it different?

Article information

Article type
Review Article
Submitted
10 Feb 2014
First published
16 Jun 2014

Nat. Prod. Rep., 2014,31, 1101-1137

Polyketide biosynthesis in dinoflagellates: what makes it different?

R. M. Van Wagoner, M. Satake and J. L. C. Wright, Nat. Prod. Rep., 2014, 31, 1101 DOI: 10.1039/C4NP00016A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements