Issue 10, 2014

Biosynthesis of fungal indole alkaloids

Abstract

Covering: up to 2014

This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to incorporate and derivatize the indole/indoline moieties in various families of fungal indole alkaloids will be discussed, including tryptophan-containing nonribosomal peptides, polyketide-nonribosomal peptide hybrids, and alkaloids derived from other indole building blocks. This review also includes a discussion regarding the downstream modifications that generate chemical and structural diversity among indole alkaloids.

Graphical abstract: Biosynthesis of fungal indole alkaloids

Article information

Article type
Review Article
Submitted
30 May 2014
First published
02 Sep 2014

Nat. Prod. Rep., 2014,31, 1474-1487

Author version available

Biosynthesis of fungal indole alkaloids

W. Xu, D. J. Gavia and Y. Tang, Nat. Prod. Rep., 2014, 31, 1474 DOI: 10.1039/C4NP00073K

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