Issue 2, 2015
From the journal:

Nanoscale

Dual-radiolabeled nanoparticle SPECT probes for bioimaging†

Kvar C. L. Black,a   Walter J. Akers,a   Gail Sudlow,a   Baogang Xu,a   Richard Laforesta  and  Samuel Achilefu*abc  

* Corresponding authors

a Department of Radiology, Washington University, St. Louis, Missouri 63110, USA

b Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63110, USA

c Department of Biochemistry & Molecular Biophysics, Washington University, St. Louis, Missouri 63110, USA
E-mail: achilefus@mir.wustl.edu

Abstract

A gold nanoparticle was radiolabeled with 125I and 111In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.

Graphical abstract: Dual-radiolabeled nanoparticle SPECT probes for bioimaging

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4NR05269B
Article type
Communication
Submitted
10 Sep 2014
Accepted
09 Nov 2014
First published
17 Nov 2014

Nanoscale, 2015,7, 440-444

Author version available

Download author version (PDF)

Permissions

Request permissions

Dual-radiolabeled nanoparticle SPECT probes for bioimaging

K. C. L. Black, W. J. Akers, G. Sudlow, B. Xu, R. Laforest and S. Achilefu, Nanoscale, 2015, 7, 440 DOI: 10.1039/C4NR05269B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements