Facile and green production of aqueous graphene dispersions for biomedical applications

Samad Ahadian; Mehdi Estili; Velappa Jayaraman Surya; Javier Ramón-Azcón; Xiaobin Liang; Hitoshi Shiku; Murugan Ramalingam; Tomokazu Matsue; Yoshio Sakka; Hojae Bae; Ken Nakajima; Yoshiyuki Kawazoe; Ali Khademhosseini

doi:10.1039/C4NR07569B

Facile and green production of aqueous graphene dispersions for biomedical applications†

Samad Ahadian,^a Mehdi Estili,*^b Velappa Jayaraman Surya,^c Javier Ramón-Azcón,^a Xiaobin Liang,^a Hitoshi Shiku,^d Murugan Ramalingam,^aef Tomokazu Matsue,^ad Yoshio Sakka,^g Hojae Bae,^h Ken Nakajima,^a Yoshiyuki Kawazoe^cm and Ali Khademhosseini*^ahijkl

Author affiliations

* Corresponding authors

^a WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan

^b International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Tsukuba 305-0047, Japan
E-mail: estili.mehdi@nims.go.jp
Fax: +81 29 859 2200

^c New Industry Creation Hatchery Center, Tohoku University, Sendai 980-8579, Japan

^d Graduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan

^e Centre for Stem Cell Research, A unit of the Institute for Stem Cell Biology and Regenerative Medicine, Christian Medical College Campus, Vellore 632002, India

^f Institut National de la Santé Et de la Recherche Médicale U977, Faculté de Chirurgie Dentaire, Université de Strasbourg, Strasbourg 67085, France

^g Materials Processing Unit, NIMS, Tsukuba 305-0047, Japan

^h College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea

ⁱ Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
E-mail: alik@rics.bwh.harvard.edu
Fax: +1 617 768 8477

^j Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

^k Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA

^l Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21569, Saudi Arabia

^m Institute of Thermophysics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia

Abstract

We proposed a facile, low cost, and green approach to produce stable aqueous graphene dispersions from graphite by sonication in aqueous bovine serum albumin (BSA) solution for biomedical applications. The production of high-quality graphene was confirmed using microscopy images, Raman spectroscopy, UV-vis spectroscopy, and XPS. In addition, ab initio calculations revealed molecular interactions between graphene and BSA. The processability of aqueous graphene dispersions was demonstrated by fabricating conductive and mechanically robust hydrogel–graphene materials.

Nanoscale

Facile and green production of aqueous graphene dispersions for biomedical applications†

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Facile and green production of aqueous graphene dispersions for biomedical applications

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