Issue 22, 2014

Rh(iii)-catalyzed regioselective hydroarylation of alkynes via directed C–H functionalization of pyridines

Abstract

Rh(III)-catalyzed C-3 selective alkenylation of pyridine derivatives via hydroarylation of alkynes has been developed. The reaction shows high regioselectivity, high yield and good functional group tolerance, providing a convenient strategy for the synthesis of trisubstituted (pyridin-3-yl)alkenes.

Graphical abstract: Rh(iii)-catalyzed regioselective hydroarylation of alkynes via directed C–H functionalization of pyridines

Supplementary files

Article information

Article type
Communication
Submitted
22 Mar 2014
Accepted
09 Apr 2014
First published
10 Apr 2014

Org. Biomol. Chem., 2014,12, 3594-3597

Author version available

Rh(III)-catalyzed regioselective hydroarylation of alkynes via directed C–H functionalization of pyridines

Z. Qian, J. Zhou, B. Li, F. Hu and B. Shi, Org. Biomol. Chem., 2014, 12, 3594 DOI: 10.1039/C4OB00612G

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