Issue 1, 2015
From the journal:

Organic & Biomolecular Chemistry

Mild Ti-mediated transformation of t-butyl thio-ethers into thio-acetates†

Thomas C. Pijper,‡a   Jort Robertus,‡b   Wesley R. Browneab  and  Ben L. Feringa*ab  

* Corresponding authors

a Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 Groningen, The Netherlands
E-mail: b.l.feringa@rug.nl

b Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 Groningen, The Netherlands

Abstract

We report a straightforward method for the rapid conversion of thio-ethers to thio-acetates using TiCl4, in good to excellent yields. The reaction conditions tolerate a variety of functional groups, including halide, nitro, ether, thiophene and acetylene functionalities. A catalytic variant of this reaction is also described.

Graphical abstract: Mild Ti-mediated transformation of t-butyl thio-ethers into thio-acetates

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Article information

DOI
https://doi.org/10.1039/C4OB02120G
Article type
Paper
Submitted
04 Oct 2014
Accepted
03 Nov 2014
First published
06 Nov 2014

Org. Biomol. Chem., 2015,13, 265-268

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Mild Ti-mediated transformation of t-butyl thio-ethers into thio-acetates

T. C. Pijper, J. Robertus, W. R. Browne and B. L. Feringa, Org. Biomol. Chem., 2015, 13, 265 DOI: 10.1039/C4OB02120G

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