Issue 1, 2015

An enantioselective total synthesis of Sch-725674

Abstract

An enantioselective total synthesis of Sch-725674, a unique 14-membered macrolactone, has been accomplished in 13 steps. The step-wise dithiane alkylation served as a strategic step to assemble the upper and lower fragments of the molecule, whereas cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction are used as key steps to complete the total synthesis.

Graphical abstract: An enantioselective total synthesis of Sch-725674

Supplementary files

Article information

Article type
Paper
Submitted
07 Oct 2014
Accepted
29 Oct 2014
First published
30 Oct 2014

Org. Biomol. Chem., 2015,13, 234-240

An enantioselective total synthesis of Sch-725674

K. Ramakrishna and K. P. Kaliappan, Org. Biomol. Chem., 2015, 13, 234 DOI: 10.1039/C4OB02136C

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