Issue 6, 2015

Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

Abstract

Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.

Graphical abstract: Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

Supplementary files

Article information

Article type
Communication
Submitted
22 Oct 2014
Accepted
25 Nov 2014
First published
25 Nov 2014

Org. Biomol. Chem., 2015,13, 1618-1623

Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

L. Ding, J. Franke and C. Hertweck, Org. Biomol. Chem., 2015, 13, 1618 DOI: 10.1039/C4OB02244K

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