Issue 9, 2015
From the journal:

Organic & Biomolecular Chemistry

Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

Patricia M. R. Pereira,ab   Barbara Korsak,a   Bruno Sarmento,cde   Rudolf J. Schneider,f   Rosa Fernandesbgh  and  João P. C. Tomé*ai  

* Corresponding authors

a QOPNA and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
E-mail: jtome@ua.pt

b Laboratory of Pharmacology and Experimental Therapeutics, IBILI – Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal

c INEB – Instituto de Engenharia Biomédica, Biocarrier Group, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal

d CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal

e Inovapotek, Pharmaceutical Research and Development, Rua Alfredo Allen 455/461, 4200-135 Porto, Portugal

f BAM Federal Institute for Materials Research and Testing, D-12205 Berlin, Germany

g Center of Investigation in Environment, Genetics and Oncobiology, 3001-301 Coimbra, Portugal

h Center of Ophthalmology and Vision Sciences, IBILI – Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal

i Department of Organic and Macromolecular Chemistry, Ghent University, B-9000 Gent, Belgium

Abstract

Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.

Graphical abstract: Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4OB02334J
Article type
Review Article
Submitted
03 Nov 2014
Accepted
06 Jan 2015
First published
06 Jan 2015

Org. Biomol. Chem., 2015,13, 2518-2529

Author version available

Download author version (PDF)

Permissions

Request permissions

Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

P. M. R. Pereira, B. Korsak, B. Sarmento, R. J. Schneider, R. Fernandes and J. P. C. Tomé, Org. Biomol. Chem., 2015, 13, 2518 DOI: 10.1039/C4OB02334J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements