Issue 9, 2015
From the journal:

Organic & Biomolecular Chemistry

A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid state†

Gary Noonan*a  and  Andrew G. Leach ORCID logo *b  

* Corresponding authors

a AstraZeneca, Alderley Park, Macclesfield, UK
E-mail: noonangary64@googlemail.com

b School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, UK
E-mail: a.g.leach@ljmu.ac.uk

Abstract

A combined experimental and computational study suggests that a reduction in the entropy of activation in the solid state can lead to the protodeboronation of boronic acids.

Graphical abstract: A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid state

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Article information

DOI
https://doi.org/10.1039/C4OB02543A
Article type
Communication
Submitted
05 Dec 2014
Accepted
09 Jan 2015
First published
21 Jan 2015
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2015,13, 2555-2560

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A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid state

G. Noonan and A. G. Leach, Org. Biomol. Chem., 2015, 13, 2555 DOI: 10.1039/C4OB02543A

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