Issue 19, 2014
From the journal:

Polymer Chemistry

Innovative well-defined primary amine-based polyacrylates for plasmid DNA complexation†

Hien The Ho,a   Sagrario Pascual,*a   Véronique Montembault,a   Nathalie Casseb  and  Laurent Fontaine*a  

* Corresponding authors

a Université du Maine, Institut des Molécules et Matériaux du Mans, Equipe Méthodologie et Synthèse des Polymères, UMR CNRS 6283, Avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France
E-mail: sagrario.pascual@univ-lemans.fr, laurent.fontaine@univ-lemans.fr
Fax: +33 (0)2 43 83 37 54
Tel: +33 (0)2 43 83 33 30

b Université du Maine, Mer, Molécules et Santé, EA 2160, Avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France

Abstract

Well-defined quaternized poly(2-aminoethyl acrylate)s (qPAEAs) have been synthesized by RAFT polymerization of N-(tert-butoxycarbonyl)aminoethyl acrylate (t-BocAEA) followed by t-Boc group deprotection. The ability of qPAEAs to act as potential “smart” DNA carriers has been shown by plasmid DNA/qPAEA complexation and qPAEA degradation in water at 37 °C without any trigger.

Graphical abstract: Innovative well-defined primary amine-based polyacrylates for plasmid DNA complexation

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Article information

DOI
https://doi.org/10.1039/C4PY00585F
Article type
Communication
Submitted
28 Apr 2014
Accepted
27 May 2014
First published
16 Jun 2014

Polym. Chem., 2014,5, 5542-5545

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Innovative well-defined primary amine-based polyacrylates for plasmid DNA complexation

H. T. Ho, S. Pascual, V. Montembault, N. Casse and L. Fontaine, Polym. Chem., 2014, 5, 5542 DOI: 10.1039/C4PY00585F

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