Issue 23, 2014

Dual stimuli-responsive supramolecular hydrogel of bionanoparticles and hyaluronan

Abstract

We report here the synthesis of a light- and chemical-responsive supramolecular hydrogel of bacteriophage M13 and hyaluronan locked by the molecular recognition between β-cyclodextrin and trans-azobenzene moieties. Compared to rod-like tobacco mosaic virus (TMV), the filamentous bacteriophage M13 with higher aspect ratio and more flexible structure formed a much more robust hydrogel with hyaluronan, which was confirmed by the inversion test and rheological measurement. The resulting M13 hydrogel showed sol–gel transition behaviours induced by either photo-irradiation or competitive host or guest molecules. Moreover, cells could be facilely encapsulated and delivered using this supramolecular hydrogel with great cell viability.

Graphical abstract: Dual stimuli-responsive supramolecular hydrogel of bionanoparticles and hyaluronan

Supplementary files

Article information

Article type
Paper
Submitted
11 Jun 2014
Accepted
06 Aug 2014
First published
07 Aug 2014

Polym. Chem., 2014,5, 6754-6760

Dual stimuli-responsive supramolecular hydrogel of bionanoparticles and hyaluronan

L. Chen, X. Zhao, Y. Lin, Z. Su and Q. Wang, Polym. Chem., 2014, 5, 6754 DOI: 10.1039/C4PY00819G

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