A new biarylmonophosphine was developed for highly asymmetric arylation and vinylation of silyl enolates of acyclic esters with good generality. The new stereocenters α to the ester groups were formed in high enantiomeric excess. The method was applied to the asymmetric synthesis of Profen drugs on a gram scale.
J. Yang and J. (. Zhou, Org. Chem. Front., 2014, 1, 365 DOI: 10.1039/C4QO00027G
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