Issue 8, 2014
From the journal:

Organic Chemistry Frontiers

Functionalized imidazoliniums from the three-component domino reaction of N-formylmethylcarboxamides with amines and isocyanides†

Chuan-Hu Lei,ab   Liang Zhao,a   De-Xian Wang,b   Jieping Zhuc  and  Mei-Xiang Wang*a  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: wangmx@mail.tsinghua.edu.cn

b Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

c Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH 5304, 1015 Lausanne, Switzerland

Abstract

In the presence of Zn(OTf)2, the three-component domino reaction of N-formylmethyl-substituted tertiary amides and enamides with amines and isocyanides in acetonitrile at room temperature produced functionalized imidazoliniums in good to excellent yields.

Graphical abstract: Functionalized imidazoliniums from the three-component domino reaction of N-formylmethylcarboxamides with amines and isocyanides

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Article information

DOI
https://doi.org/10.1039/C4QO00203B
Article type
Research Article
Submitted
21 Jul 2014
Accepted
17 Aug 2014
First published
18 Aug 2014

Org. Chem. Front., 2014,1, 909-913

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Functionalized imidazoliniums from the three-component domino reaction of N-formylmethylcarboxamides with amines and isocyanides

C. Lei, L. Zhao, D. Wang, J. Zhu and M. Wang, Org. Chem. Front., 2014, 1, 909 DOI: 10.1039/C4QO00203B

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