Issue 37, 2014

New rearranged limonoids from Walsura cochinchinensis

Abstract

Sixteen new limonoids, walsucochinoids C–R (1–16) incorporating a rearranged carbon skeleton, were isolated from the twigs and leaves of Walsura cochinchinensis. Their structures were established by detailed interpretation of spectroscopic data with those of 1 and 10 being secured by single-crystal X-ray diffraction experiments. Bioassays revealed that walsucochinoids D (2) and E (3) were mild mouse and human 11β-HSD1 inhibitors with IC50 values of 13.4 ± 1.7 and 8.25 ± 0.69 μM, respectively.

Graphical abstract: New rearranged limonoids from Walsura cochinchinensis

Supplementary files

Article information

Article type
Paper
Submitted
24 Jan 2014
Accepted
04 Mar 2014
First published
05 Mar 2014

RSC Adv., 2014,4, 19150-19158

Author version available

New rearranged limonoids from Walsura cochinchinensis

M. Han, Y. Shen, Y. Leng, H. Zhang and J. Yue, RSC Adv., 2014, 4, 19150 DOI: 10.1039/C4RA00708E

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