Issue 29, 2014

L-proline catalyzed multicomponent reactions: facile access to 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives

Abstract

A series of 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives has been synthesized from the three component reactions of 2-hydroxy-1,4-naphthoquinone, aldehydes, and aminopyrazoles in the presence of a catalytic amount of L-proline. This domino reaction proceeds smoothly in good to excellent yields and offers several advantages including no column chromatography, a simple reaction procedure, metal-free reaction conditions and being applicable to a broad range of aldehydes.

Graphical abstract: L-proline catalyzed multicomponent reactions: facile access to 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives

Supplementary files

Article information

Article type
Paper
Submitted
30 Jan 2014
Accepted
14 Mar 2014
First published
14 Mar 2014

RSC Adv., 2014,4, 15319-15324

Author version available

L-proline catalyzed multicomponent reactions: facile access to 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives

S. Karamthulla, S. Pal, T. Parvin and L. H. Choudhury, RSC Adv., 2014, 4, 15319 DOI: 10.1039/C4RA00876F

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