Tetrahydropyranyl ether (THPE) formation in hydroxyl group protection and conversion to other useful functionalities

Abstract

This short review highlights the various methods of formation of tetrahydropyranyl ethers (THPEs) as a method for the protection of simple alcohols as well as a diverse range of complex molecules using a variety of reagents and reaction conditions, i.e., acid catalyst, heterogeneous catalyst and neutral reagent mediated reactions. We also discuss their direct conversion to other useful functionalities.