Issue 33, 2014
From the journal:

RSC Advances

An approach to 6-trifluoromethyl-phenanthridines through visible-light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides†

Weijun Fu,*a   Mei Zhu,a   Fengjuan Xu,b   Yuqin Fu,a   Chen Xua  and  Dapeng Zoub  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, Henan 471022, PR China
E-mail: wjfu@lynu.edu.cn

b College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450052, PR China

Abstract

A mild and efficient visible light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides is developed for the synthesis of 6-(trifluoromethyl)phenanthridine derivatives. The reaction involves the generation of radical intermediates from C(sp2)–Cl bonds and a homolytic radical aromatic substitution (HAS) process.

Graphical abstract: An approach to 6-trifluoromethyl-phenanthridines through visible-light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides

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Article information

DOI
https://doi.org/10.1039/C4RA02384F
Article type
Communication
Submitted
25 Feb 2014
Accepted
28 Mar 2014
First published
28 Mar 2014

RSC Adv., 2014,4, 17226-17229

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An approach to 6-trifluoromethyl-phenanthridines through visible-light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides

W. Fu, M. Zhu, F. Xu, Y. Fu, C. Xu and D. Zou, RSC Adv., 2014, 4, 17226 DOI: 10.1039/C4RA02384F

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