Issue 42, 2014

Recent advances and perspectives in copper-catalyzed Sonogashira coupling reactions

Abstract

C–C bond formation using transition metal catalyzed Sonogashira coupling reaction is an indispensable tool in synthetic organic chemistry. Initially Pd complexes were used as catalysts; however advances in catalyst design fuelled the development of Cu catalysts, which are cheaper and more environmentally benign than the Pd complexes. This is the first review reported so far dealing exclusively with Cu-catalyzed Sonogashira coupling reactions. This review illustrates the current strategies and potential of Cu-catalyzed Sonogashira coupling reactions.

Graphical abstract: Recent advances and perspectives in copper-catalyzed Sonogashira coupling reactions

Article information

Article type
Review Article
Submitted
22 Mar 2014
Accepted
02 May 2014
First published
20 May 2014

RSC Adv., 2014,4, 21688-21698

Author version available

Recent advances and perspectives in copper-catalyzed Sonogashira coupling reactions

A. M. Thomas, A. Sujatha and G. Anilkumar, RSC Adv., 2014, 4, 21688 DOI: 10.1039/C4RA02529F

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