Issue 81, 2014

WCl6/DMF as a new reagent system for the phosphine-free Pd(0)-catalyzed aminocarbonylation of aryl halides

Abstract

WCl6 in dimethyl formamide (DMF) is introduced as a new reagent system for aminocarbonylation of aryl halides in the presence of PdCl2 as pre-catalyst without any phosphorous ligand. Aryl iodides, bromides as well as chlorides were efficiently converted to their corresponding N,N-dimethyl amides in good to high yields. In this protocol, WCl6/DMF is responsible for the generation of both Pd(0) catalyst as well as the formation of a Vilsmeier imminium type intermediate.

Graphical abstract: WCl6/DMF as a new reagent system for the phosphine-free Pd(0)-catalyzed aminocarbonylation of aryl halides

Supplementary files

Article information

Article type
Paper
Submitted
18 May 2014
Accepted
03 Sep 2014
First published
04 Sep 2014

RSC Adv., 2014,4, 43178-43182

WCl6/DMF as a new reagent system for the phosphine-free Pd(0)-catalyzed aminocarbonylation of aryl halides

N. Iranpoor, H. Firouzabadi, Z. T. Rizi and S. Erfan, RSC Adv., 2014, 4, 43178 DOI: 10.1039/C4RA04673K

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