Issue 63, 2014

Detection of adenine-rich ssDNA based on thymine-substituted tetraphenylethene with aggregation-induced emission characteristics

Abstract

In this work, tetraphenylethene (TPE) equipped with thymine, TPE–T, was synthesized and used as a fluorescence biosensor for differentiating ssDNA from dsDNA. TPE–T is a “turn-on” fluorescence probe once it forms hydrogen bonds with single-stranded adenine-containing oligonucleotides with high sensitivity and specificity. The working mechanism of TPE–T and its potential in cell imaging are investigated in detail.

Graphical abstract: Detection of adenine-rich ssDNA based on thymine-substituted tetraphenylethene with aggregation-induced emission characteristics

Supplementary files

Article information

Article type
Paper
Submitted
15 Jun 2014
Accepted
14 Jul 2014
First published
16 Jul 2014

RSC Adv., 2014,4, 33307-33311

Detection of adenine-rich ssDNA based on thymine-substituted tetraphenylethene with aggregation-induced emission characteristics

X. Lou, C. W. T. Leung, C. Dong, Y. Hong, S. Chen, E. Zhao, J. W. Y. Lam and B. Z. Tang, RSC Adv., 2014, 4, 33307 DOI: 10.1039/C4RA05765A

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