Issue 69, 2014

A novel fluorescent pH probe with valuable pKa based on a twisted intramolecular charge transfer mechanism, and its applications in cell imaging

Abstract

A novel structurally simple and easily prepared pH probe based on a twisted intramolecular charge transfer signalling mechanism, namely Napa-pp, has been designed and synthesized. In aqueous buffer solution, it has a valuable pKa of 5.32 that matches the typical pH range of acidic organelles, hence it is applicable for visualizing lysosomes in living cells.

Graphical abstract: A novel fluorescent pH probe with valuable pKa based on a twisted intramolecular charge transfer mechanism, and its applications in cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
09 Jul 2014
Accepted
13 Aug 2014
First published
20 Aug 2014

RSC Adv., 2014,4, 36849-36853

Author version available

A novel fluorescent pH probe with valuable pKa based on a twisted intramolecular charge transfer mechanism, and its applications in cell imaging

F. Yu, Y. Wang, W. Zhu, Y. Huang, M. Yang, H. Ai and Z. Lu, RSC Adv., 2014, 4, 36849 DOI: 10.1039/C4RA06834C

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