Issue 98, 2014
From the journal:

RSC Advances

Interaction of graphene oxide with human serum albumin and its mechanism†

Zhijia Ding,abc   Hongwei Maa  and  Yanyan Chen*a  

* Corresponding authors

a Key Laboratory for Nano-Bio Interface Research, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, P. R. China
E-mail: Yanyanchen2006@sinano.ac.cn

b Institute of Biophysics, Chinese Academy of Sciences, Beijing, P. R. China

c University of Chinese Academy of Sciences, Beijing, P. R. China

Abstract

Human serum albumin (HSA) is chosen to investigate the interaction of graphene oxide-based nanosheets (GONS) with plasma proteins in terms of binding affinity, action mechanism, conformational change and function loss. We show that GONS inhibit HSA function via two routes: blocking protein active sites, or destroying protein structure.

Graphical abstract: Interaction of graphene oxide with human serum albumin and its mechanism

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Article information

DOI
https://doi.org/10.1039/C4RA09613D
Article type
Communication
Submitted
02 Sep 2014
Accepted
23 Oct 2014
First published
24 Oct 2014

RSC Adv., 2014,4, 55290-55295

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Interaction of graphene oxide with human serum albumin and its mechanism

Z. Ding, H. Ma and Y. Chen, RSC Adv., 2014, 4, 55290 DOI: 10.1039/C4RA09613D

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