Issue 103, 2014

Fabrication of mesoporous silica nanoparticles hybridised with fluorescent AIE-active quinoline-malononitrile for drug delivery and bioimaging

Abstract

A novel type of fluorescent mesoporous silica nanoparticle (FMSN) has been successfully synthesised by hybridising mesoporous silica nanospheres with an aggregation-induced emission luminogen, a quinoline-malononitrile derivative. The FMSNs with uniform morphology show excellent AIE-active luminescence and good biocompatibility. Transmission electron microscopy (TEM) demonstrates that the well-ordered mesoporous structure in FMSNs is beneficial for drug delivery. When loaded with doxorubicin (DOX), DOX@FMSNs demonstrate pH-dependent release character and high cytotoxicity towards MCF-7 cancer cells. These FMSNs are expected to be promising multifunctional candidates as both bioimaging agents and drug carriers in cancer therapy.

Graphical abstract: Fabrication of mesoporous silica nanoparticles hybridised with fluorescent AIE-active quinoline-malononitrile for drug delivery and bioimaging

Supplementary files

Article information

Article type
Paper
Submitted
10 Sep 2014
Accepted
27 Oct 2014
First published
27 Oct 2014

RSC Adv., 2014,4, 58976-58981

Fabrication of mesoporous silica nanoparticles hybridised with fluorescent AIE-active quinoline-malononitrile for drug delivery and bioimaging

S. Yao, A. Shao, W. Zhao, S. Zhu, P. Shi, Z. Guo, W. Zhu and J. Shi, RSC Adv., 2014, 4, 58976 DOI: 10.1039/C4RA10114F

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