Issue 108, 2014

Streptospirodienoic acids A and B, 6,6-spiroketal polyketides from Streptomyces sp.

Abstract

Three new 6,6-spiroketal polyketides, streptospirodienoic acids A (1), B (2) and streptospirodienoate A (3), were obtained from the fermentation broth of Streptomycetes sp. (no. 0950134). Their structures were constructed by one 6,6-spiroketal core coupled with hexadienoic acid, in which the starter unit might be 2-methylpropionyl-CoA. Their chemical structures were determined by detailed analyses of UV, IR, HRESIMS, 1D, 2D-NMR spectroscopic data and the X-ray crystallography technique. The biosynthetic pathway for 1 and 2 was proposed. Compound 3 showed moderate cytotoxic activity against HCT-116 cells (IC50 = 5.2 μM), while compounds 1 and 2 showed no activity (IC50 > 10.0 μM).

Graphical abstract: Streptospirodienoic acids A and B, 6,6-spiroketal polyketides from Streptomyces sp.

Supplementary files

Article information

Article type
Communication
Submitted
18 Sep 2014
Accepted
04 Nov 2014
First published
05 Nov 2014

RSC Adv., 2014,4, 63324-63327

Streptospirodienoic acids A and B, 6,6-spiroketal polyketides from Streptomyces sp.

Y. Chen, Q. Liu, H. Gao, H. Lin, H. Tian, K. Hong, J. Li, R. Jiang, X. Yao and J. Tang, RSC Adv., 2014, 4, 63324 DOI: 10.1039/C4RA10672E

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