A copper-catalyzed 8-amide chelation-assisted C–H alkylation of 8-aminoquinolines is described. The secondary and tertiary alkyl carboxylic acids can be used as alkylating agents. This reaction allows for the highly regioselective preparation of C2-adamantyl 8-aminoquinoline scaffolds by the decarboxylative alkylation catalytic system.
X. Xia, S. Zhu, Z. Gu and H. Wang, RSC Adv., 2015, 5, 28892 DOI: 10.1039/C4RA16896H
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