Transition metal-free asymmetric and diastereoselective allylic alkylation using Grignard reagents: construction of vicinal stereogenic centers via kinetic resolution

Abstract

The first transition metal-free diastereoselective and enantioselective asymmetric allylic alkylation (AAA) has been disclosed leading to the construction of vicinal tertiary/quaternary centers via a kinetic resolution protocol starting from readily available starting materials. This procedure is chemically appealing since no consecutive AAA or stereoselective metal-catalyzed/chiral ligand AAAs are required to construct the two stereocenters.