Issue 10, 2014

A cooperative N-heterocyclic carbene/palladium catalysis system

Abstract

N-heterocyclic carbenes (NHC) have been extensively studied as organocatalysts and ligands for transition metals, but the successful integration of NHCs and late transition metals in cooperative catalysis remains an underexplored area. We have developed a cooperative palladium-catalyzed allylation of NHC-activated aldehydes to access a variety of 3-allyl dihydrocoumarin derivatives. Kinetic experiments support a cooperative pathway for this transformation.

Graphical abstract: A cooperative N-heterocyclic carbene/palladium catalysis system

Supplementary files

Article information

Article type
Edge Article
Submitted
24 May 2014
Accepted
20 Jun 2014
First published
23 Jul 2014

Chem. Sci., 2014,5, 4026-4031

A cooperative N-heterocyclic carbene/palladium catalysis system

K. Liu, M. T. Hovey and K. A. Scheidt, Chem. Sci., 2014, 5, 4026 DOI: 10.1039/C4SC01536C

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