Issue 41, 2014

Micelles consisting of choline phosphate-bearing Calix[4]arene lipids

Abstract

We synthesized new calix[4]arene-based lipids, denoted by CPCaLn, bearing the choline phosphate (CP) group which is an inverse phosphoryl choline (PC) structure. Small-angle X-ray scattering and multi-angle light scattering coupled with field flow fractionation showed that these lipids form monodisperse micelles with a fixed aggregation number and diameters of 1.9 and 2.6 nm for lipids bearing C3 and C6 alkyl tails, respectively. Furthermore, when CPCaLn was mixed with the fluorescein isothiocyanate (FITC)-bearing lipids and added to cells, strong fluorescence was observed at 37 °C, but not at 4 °C, indicating that the micelles were taken up by the cells through endocytosis. Recent studies have shown that replacement of polymer-attached PC groups with CP groups markedly promotes cellular uptake, even though the surface charge is neutral. On the basis of the idea, CPCaLn micelles interacted with cells in the same way, suggesting that the micelles bearing CP groups are expected to use as carriers in the drug delivery system.

Graphical abstract: Micelles consisting of choline phosphate-bearing Calix[4]arene lipids

Supplementary files

Article information

Article type
Paper
Submitted
23 Jun 2014
Accepted
08 Aug 2014
First published
08 Aug 2014

Soft Matter, 2014,10, 8216-8223

Author version available

Micelles consisting of choline phosphate-bearing Calix[4]arene lipids

S. Fujii, K. Nishina, S. Yamada, S. Mochizuki, N. Ohta, A. Takahara and K. Sakurai, Soft Matter, 2014, 10, 8216 DOI: 10.1039/C4SM01355G

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